Not medical advice FMF Companion is an educational synthesis of published literature for study and patient understanding. It does not replace a clinician. Doses and guideline statements are reported as published, not as instructions for any individual.
Familial Mediterranean fever: an animated, cited guide
This page needs JavaScript for its animations. The outline and key answers are below, and every claim in the full version carries a numbered citation.
Not medical advice. FMF Companion is an educational synthesis of published literature. It does not replace a clinician.
What is in it
What FMF is The gene and inheritance Pyrin, animated An attack, hour by hour Colchicine inside the cell Colchicine over months Dosing, safety and interactions AA amyloidosis Diagnosis and criteria The differential The treatment ladder Living with FMF Toward a cure History and people Flashcards, quiz and glossary Sources
Part 2 · Colchicine
Colchicine over months
Colchicine is not a painkiller and does not stop an attack that has already started. Its benefit builds as the drug settles into white cells and as weeks pass without the inflammation that would have happened. Drag through two years, then zoom out to decades.
Scenario
Full response, daily doses
Partial response
Many missed doses
Colchicine-resistant
Play Months
Illustrative model. No study has published a week-by-week curve of SAA or attack rate after starting colchicine. The shapes follow what is published: leukocyte pharmacokinetics, response judged over 3–6 months, SAA falling after dose increases, and long-term cohort outcomes. It is not a prediction for any person.
Zoom out: decades and amyloidosis