Not medical advice MS Companion is an educational synthesis of published literature for study and patient understanding. It does not replace a neurologist or MS nurse. Doses, criteria and guideline statements are reported as published, not as instructions for any individual. Never stop or switch a medicine without your own team.
Multiple sclerosis: an animated, cited guide
This page needs JavaScript for its animations. The outline and key answers are below, and every claim in the full version carries a numbered citation.
Not medical advice. MS Companion is an educational synthesis of published literature. It does not replace a clinician.
What is in it
What MS is Who gets it, the numbers, and where in the nervous system it strikes.
Myelin and demyelination How signals jump along a myelinated nerve fibre, and what a lesion does to them.
The immune attack T cells, B cells and the blood-brain barrier, step by step.
Genes and risk factors HLA-DRB1*15:01, Epstein-Barr virus, vitamin D, smoking and teenage obesity.
Relapse and remission over time Relapsing, secondary progressive and primary progressive MS on one timeline.
A relapse, week by week Onset, steroids and recovery, and how a pseudo-relapse differs.
Measuring disability: EDSS The 0 to 10 scale and what confirmed worsening means.
McDonald criteria calculator Dissemination in space and time, CSF, and the 2017 and 2024 rules.
The differential NMOSD, MOGAD and other conditions that look like MS.
How the drugs work Where each disease-modifying therapy acts.
The DMT ladder Escalation, early high-efficacy treatment and stopping in later life.
Safety and monitoring PML and the JCV index, infections, vaccines and rebound.
Toward a cure Remyelination, BTK inhibitors, stem-cell transplantation and EBV.
Symptoms and rehabilitation Fatigue, spasticity, bladder, walking, mood and cognition.
Living with MS Pregnancy, work, heat, exercise and planning.
Nursing care Assessment, giving the medicines, monitoring and teaching.
History and people From Carswell and Charcot to the 2024 criteria.
Flashcards, quiz and glossary Revision for students.
Sources Every reference behind the app.
Part 6 · Context & review
Flashcards & mnemonics
Flashcards on multiple sclerosis, from myelin and Epstein-Barr virus to McDonald 2024, DMTs and pregnancy. Tap a card or press Space to flip it; arrow keys move through the deck. Filter by part, or shuffle.
← Previous Flip Next → Shuffle
Mnemonics
Mnemonic in motion: two places, two times
Play the case to watch lesions appear in two places and at two times, and see when each part of the McDonald rule is met.
Play Timeline
Schematic case, not to scale. Numbers mark the five McDonald 2024 topographies.